Anabolic Steroids

Posted by Samer Debs on

What are Anabolic Steroids?

Anabolic steroids (also known as androgenic steroids) are synthetic derivatives of testosterone.

There are two types of anabolic steroids:

  1. 17 alpha alkyl derivatives
  2. 17 beta ester derivatives

Examples of more popular Anabolic Steroids:

Testosterone Cypionate, Testosterone Enanthate, Testosterone Propionate, Nandrolone Decanoate, Nandrolone Phenpropionate, and dromostanolone aka Masteron.

Nandrolone Phenpropionate is a C18 androgenic anabolic steroid and was one of the first anabolic steroids to be used as a doping agent by professional athletes in the 1960s. It was banned from the Olympics by the IOC in 1974.

How Do Anabolic Steroids Work?

Endogenous anabolic steroids such as testosterone and dihydrotestosterone and synthetic anabolic steroids mediate their effects by binding to and activating androgen receptors. In skeletal muscle, anabolic steroids regulate the transcription of target genes that control the accumulation of DNA in skeletal muscle required for muscle growth.

Anabolic steroids also upregulate and increase the number of androgen receptors, thus enabling increased training intensity, and thereby indirectly contributing to an increase in muscle size and strength. They also have a stimulatory effect on the brain through their diverse effects on various central nervous system neurotransmitters, antagonism of glucocorticoids, and stimulation of the growth hormone-insulin-like growth factor-1 axis.

Nandrolone Decanoate and Nandrolone Phenpropionate are associated with the increased ratio of anabolic activity versus androgenic activity. Nandrolone decanoate is a slow-acting anabolic steroid designed for the sole purpose of increasing muscle mass. It acts by promoting nitrogen retention in muscles leading to an increase in muscle size, and provide joint pain relief by promoting the synthesis of collagen and the enhancement of bone mineralization. Nandrolone phenpropionate also causes an increase in muscle growth, stimulation of appetite, and an increase in the production of red blood cells.

Dromostanolone (Masteron) is a synthetic anabolic steroid with anti-estrogenic properties and is five times more potent than methyltestosterone, which is being used widely by bodybuilders to prepare for competition. It increases retention of nitrogen, phosphorus, and potassium, resulting in an increase of protein anabolism and a decrease in the catabolism of amino acids, leading to an increase in density and hardness of muscle.

https://www.ncbi.nlm.nih.gov/books/NBK482418/


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